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Abbreviations AsA: Ascorbate APX: Ascorbate peroxidase BCAT-like1: Branched chain aminotransferase proteins like 1 BLASTP: Protein Basic Local Alignment Search Tool CDNB: 1chlopro2,4dinitrobenzene DEGs: Differently expressed genes DEMs: Differently expressed metabolites DHAR: Dehydroascorbate reductase DRTS: Bifunctional dihydrofolate reductase-thymidylate EC: Enzyme Nomenclature folC: Dihydrofolate synthase G6PD: Glucose 6-phosphate dehydrogenase GMPS: Nucleotide guanosine 5-monophosphate synthase GO: Gene Ontology GPX: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione GSSG: Oxidized glutathione GST: Glutathione S-transferase KEGG: Kyoto Encyclopedia of Genes and Genomes LED: Light-emitting diode NCBI: National Center for Biotechnology Information NADP+: Dependent isocitrate dehydrogenase NADPH: Nicotinamide ademine dinucleotidephosphate ROS: Reactive oxygen species Spe: Spermidine SpeE: Spermidine synthase UV-C: Ultraviolet-C References Chasseaud L

In addition to the better-studied pathogenesis of ILCs in psoriasis, contributions of NK cell-mediated innate immune responses to inflammatory skin diseases, especially psoriasis, have shown increasingly emerging [113,114,115]

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Internal processes continue developing tolerance even when external signs look normal