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Although folic acid fortification has been highly effective in reducing neural tube defects, accumulating evidence and recent reviews have raised concerns that chronic UMFA exposure may have unintended consequences, including potential effects on cancer risk, immune function, epigenetic regulation, and neurodevelopment, though findings remain conflicting, and causality is not established

Direct comparison of MG toxicity in primary cultures of mouse cortical neurons and astrocytes evidenced a 6-fold higher susceptibility toward MG toxicity in neurons compared to astrocytes (Blanger et al., Neuronal MG toxicity is associated with AGEs production and accumulation (Blanger et al., 2004, 2008
An antioxidant called glutathione is made up of three amino acids and is a naturally occurring antioxidant

Prez-Gutirrez L, Ferrara N
