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Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery

The latter option, that loss of oxidants can augment apoptosis, is supported by findings that correlate increased cellular hydrogen peroxide levels with resistance to apoptotic signaling in some cell systems (18, 86), as catalase overexpression in either cytoplasmic or mitochondrial compartments potentiated apoptosis, whereas inhibiting endogenous catalase promoted cell survival

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Similarly, an experiment conducted in transgenic mice demonstrated that administration of vitamin E can rescue formation of an embryonic inner cell mass in GPx4 -/- KO mice [66]