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Unlike conventional chemotherapeutic agents, curcumin can simultaneously modulate several critical oncogenic signaling pathways implicated in prostate cancer pathogenesis, such as phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin, nuclear factor kappa B, Wnt/-catenin, signal transducer and activator of transcription 3, and androgen receptor signaling (Shanmugam et al., 2015

Psychiatry 35 , 451455 (1972)

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Until these fundamental questions are answered, the best we can do is to continue to reduce the ratio of omega 6/omega 3 in our dietary supply of PUFA (which currently is around 10.0 compared to 12.0 just a few years ago) by increasing consumption of fish and certain plant oils, to what is considered an ideal ratio of 2.3/1.0 [37]