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The relationship between excitotoxicity and ALS can be exemplified by the finding that the cerebrospinal fluid of patients with the disease had three-fold higher concentrations of glutamate, aspartate, N -acetyl-aspartyl glutamate, and N -acetyl aspartate when compared to healthy controls [199]

Acknowledgments The authors acknowledged that the manuscript had undergone a thorough review and received unanimous approval, thereby consenting to its submission to the Journal

The decline of macrophage phagocytosis was linked to changes in the aged tissue microenvironment, including increased immune cells and IL-10 from B cells