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doi: 10.1093/jn/133.2.381
Interestingly, down-regulation of immediate early genes, altered synaptic signaling, an anxiety-like behavior, and mild neuronal loss have been observed in these transgenic mice, suggesting that increased TMEM106B levels negatively impact brain health [199]
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Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury
