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7.4 Alkaloids: suppressors of apoptosis and metabolic dysfunction Alkaloids attenuate ALD by suppressing the MAPK/NF-B axis, thereby reducing ERK/JNK phosphorylation and TNF- production, which mitigates hepatocyte apoptosis ( Oxymatrine, a quinolizidine alkaloid from the roots of Sophora flavescens Aiton [Fabaceae], inhibits ERK1/2-mediated apoptosis and downregulates pro-inflammatory cytokines ( Berberine, an isoquinoline alkaloid from traditional Chinese medicinal herbs such as Coptis chinensis Franch

Lycopene: Lycopene is a natural, plant-derived carotenoid pigment that provides the red color of tomatoes, watermelon, and other fruits

Nature 600 , 500505 (2021)

Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: Role of the innate immune response in Celiac disease