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In contrast, HIF-1 deficiency favors Treg expansion and suppresses osteoclastic activity

The number of pro-inflammatory M1 macrophages was reduced in the neural sections and the number of anti-inflammatory M2 macrophages was increased in db/db mice (fed a high-concentration iron diet)

In contrast, L-serine can inhibit the growth of certain bacterial strains and enhance the efficacy of antibiotic treatment 102,103

However, asthmatic and GliSODin-treated mice exhibited the same levels of HDM-specific IgG1 and IgG2a, and IgG1 and IgG2a levels were higher and lower, respectively, than the control (Supplementary Figure S1B,C)