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This effect is mediated via the opioid receptor, either directly or indirectly

There are two genes in particular that are evaluated for MTHFR, and these may exist in a homozygous (meaning there are two copies of the gene) or heterozygous (only one copy) form

This action results in a reduction of melanin content in the epidermis and could potentially help lighten the periorbital area, although clinical studies would be necessary to confirm this

Because of their narrow width, they do not shadow in flat lighting the way boxcar scars do, but in raking light or close-up they are clearly visible as deep puncture-like marks that are difficult to cover with makeup