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The so-called myokines, produced by the myocytes and released by muscle contraction during physical exercise, have autocrine, paracrine, and endocrine functions, and help perform the regulation of the immunometabolism thanks to their ability to induce significant metabolic, energetic and hormonal changes (Pillon et al., 2013
doi: 10.2147/COPD.S51226 27 SmithCPerfettiTKingJ
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