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However, obesity causes resistance to the beneficial effects of leptin (Galic 2010)

Melanotan 1 has a half-life of approximately 1.5 hours when administered subcutaneously, so some researchers have administered the peptide twice daily to skin disorder patients to maintain therapeutic levels [17]

However, long-term use can irritate skin (redness, itchiness) and, in rare cases, cause a bluish discoloration called exogenous ochronosis

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