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Engaging all three pathways simultaneously drives glucose-dependent insulin secretion through the two incretin arms while adding glucagon-receptor agonism implicated in energy expenditure, the pharmacological rationale that distinguishes it from single (GLP-1 (Sema)) and dual (GLP-2 (Triz)) incretin agonists

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[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Takayanagi M, Wentz J, Takayanagi Y, Schretlen DJ, Ceyhan E, Wang L, Suzuki M, Sawa A, Barta PE, Ratnanather JT, Cascella NG

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