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Given that the combined therapy is usually prescribed to different subtypes of SCZ and the antidepressant was typically prescribed to patients with prominent negative symptoms, the disease subtype bias beyond drug effect should be carefully considered

doi: 10.1073/pnas.90.8.3636 285 NakamuraI.YoshimuraS.MasakiT.TakaseS.OhsumiK.HashimotoM.et al

Considering the importance of phenoconversion, Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines suggest incorporating the effects of CYP2D6 inhibitors while calculating the activity score of CYP2D6 for CYP2D6 metabolized opioids, tricyclic antidepressants, tamoxifen and atomoxetine

Note on B12 Injections We offer B12 injections only after a thorough assessment