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Elderly persons tend to have a higher adipose to muscle tissue ratio, and this is therefore one reason why the half-life of some drugs, such as diazepam, is greater in the elderly

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Opioid and Nociceptin Receptors Regulate Cytokine and Cytokine Receptor Expression

In addition, toxic or pathologic conditions that lead to an impairment of mitochondrial function can increase the release of ROS