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Journal of Applied Physiology , 109(5), 13721378

The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications

RF microneedling is considered safer and more predictable for melanin-rich skin tones than ablative laser approaches, and combining it with GHK-Cu addresses both the structural deficit and the inflammatory component that often drives post-inflammatory hyperpigmentation in these patients

Akin, E
