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Description
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Cardiovasc Res 2009;82:9-20
It is mediated by kinesin-1, which binds to mitochondria via anchoring proteins including the microtubule-associated motors dynein-dynactin, the Ca 2+ -dependent mitochondrial Rho GTPase 1 (Miro1), and the trafficking kinesin proteins 1 and 2 [45]
In some embodiments, the otic formulation or composition comprises between about 0.001% to about 99.99% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof
