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Epidemiology 50% of all acute liver failure cases in the United States are attributable to APAP of these cases are intentional and are unintentional (Larson 2005) Of those that are unintentional, 63% of cases occur in patients taking APAP-opioid combinations (Larson 2005) Mortality from acute liver failure secondary to APAP approaches 30% (Blieden 2014) Clinical Presentation Key Point: The first stage of APAP toxicity is largely silent

Many patients report feeling benefits such as increased energy, improved focus, or reduced pain shortly after treatment

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COPD