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Therefore, a better understanding of the pathophysiological mechanisms involved in HT initiation and progression (including oxidative stress, inflammation, immune imbalance, etc.) may facilitate rational strategies to prevent the irreversible destruction of the thyroid parenchyma

Vitamin C A powerful antioxidant that supports immune function and collagen production

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on the other hand, it can be a factor in the failure of molecularly targeted therapy ( Furthermore, at present, the assessment for ferroptosis are limited to propidium iodide staining, transmission electron microscopy for morphological observation of shrinking mitochondria, and measurement of intracellular reactive oxygen species, 4-hydroxynonenal and malondialdehyde ( , are also potential ferroptosis markers