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When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced
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Options include increasing concentration, adding microneedling, incorporating other treatments like minoxidil, or switching to GHK-Cu to test whether the alternative copper peptide produces better individual response
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