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This will allow for a more faithful modeling of this disease and gain insights into the underlying molecular mechanisms caused by mitochondrial dysfunction and gain insights into underlying molecular mechanisms produced by mitochondrial dysfunction and altered redox state with reactive oxygen species (ROS) overproduction found in 2D models (Villanueva-Paz et al., 2019), and how these alterations might affect cell fate and interactions between neuronal populations

doi: 10.1016/j.metabol.2015.10.014 46

in addition to which, the -chains also have an inhibitory effect on the polymerization process

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