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Then, the quantification result was corrected using a R package Accucor (v0.3.0) 47 for natural isotope correction

Acknowledgments We would like to thank Michelle Abadie, Thayn Mendes, Juliane Heyde, and Matheus Kingeski for their sample support and information on the species studied, and Luis Esteban Krause Lanes (PUCRS) for his valuable help in the statistical analysis of the work

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A meta-analysis evaluating 13 studies and a total of 4155 people with COPD concluded that the standard dose of 1200 milligrams of N -acetylcysteine per day reduces the incidence and severity of flares (known as exacerbations) compared to a placebo [104]