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Randomized, placebo-controlled, phase III trial of yeast-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) versus peptide vaccination versus GM-CSF plus peptide vaccination versus placebo in patients with no evidence of disease after complete surgical resection of locally advanced and/or stage IV melanoma: a trial of the Eastern Cooperative Oncology GroupAmerican College of Radiology Imaging Network Cancer Research Group (E4697)

injection) Neffy (nasal spray) (FDA approval August 9, 2024) Generic Drug Class: Catecholamine, Sympathomimetic, Medication & Hormone Mechanism of Action: Epinephrine stimulates both 1 & 2 and 1 & 2 receptor subtypes on tissues expressing these various adrenergic receptors

KDS12025 and HTPEB also fit within the narrow catalytic pocket of HRP (Supplementary Fig