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Additionally, hypoxia-induced downregulation of nuclear receptor coactivator 4 and p53 polymorphisms also control the susceptibility of macrophages to ferroptosis (84)

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To achieve this objective, critical research priorities in subsequent clinical trials include: standardization of ESCM extracts, determination of safe dosage ranges, the differences in bioavailability of each constituent and their corresponding combination methods, as well as the development of personalized therapeutic regimens stratified by cancer subtypes

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