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Interpreting limits of past ULT trials A guiding doctrine of the ACP guideline was that retrospective studies and even RCTs that used the decline in serum urate level to a pre-stipulated target as an indirect, surrogate outcome, rather than demonstrating the improvement in a clinical outcome such as reduction in frequency of acute gout flares during the randomized phase of an RCT, were insufficient data for the standard of evidence-based guidelines defined by the Institute of Medicine (since renamed the National Academy of Medicine) 40

The fine-mist application allows for flexibility while facilitating delivery through non-digestive pathways

A majority of its supplements cost between $10 and $30 for a single bottle, though they can cost as much as $75 or as little as $4

It's an oil-soluble form of Vitamin C that is significantly more stable than the more common L-Ascorbic Acid