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The oral mucosa has two main layers: the lamina propria, which supplies blood vessels and support, and the outer stratified squamous epithelium, which protects the tissue (Figure 2 right)

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The possible molecular mechanism underlying OPs anti-photoaging is possibly related to downregulating of the MAPK/NF-B signaling pathway, while promoting TGF- production in the skin

A suboptimal diet and gut microbiome (low microbiota diversity) might compromise absorption of exogenous antioxidants, enhancing the pro-oxidative damage wreaked by Hcy