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[25] Metabolic effects [edit] As a major growth factor, IGF1 is responsible for stimulating growth of all cell types, and causing significant metabolic effects

Tumor cells with mesenchymal phenotype are resistant to the dual IGF-IR/InsR inhibitor linsitinib, due to the decreased expression of IGF2 and InsR, and phosphorylation of IGF-IR/InsR in these cells [182]

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