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Among them, although troglitazone has a low inhibitory effect on ACSL4, it may have inherent antioxidant activity due to its 6-chromanol structure, and it has the strongest ferroptosis inhibitory effect among thiazolidinediones [14]
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Therefore, the -elimination reaction may account for the binding of a metabolite of methazolamide to macromolecules and for the specific ocular toxicity (Kishida et al., 2001)
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