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This implies that these regions in the homotetrameric form of ApoE are covered and inaccessible to proteases

Both ROS and inflammatory signals interact with HIF-1 in a complex and reciprocal manner with both inducing HIF-1 expression and stabilizing its protein level, while HIF-1 that affects ROS production and inflammation

Tang, R., Dodd, A., Lai, D., Mcnabb, W
