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Thus, maintained surveillance is required in individuals at high risk, and the two-step method of digital follow-up allows detection of melanomas with few dermatoscopic criteria by digital dermoscopy follow-up (60 % of the new melanomas diagnosed in DFU) and also the detection of melanoma that present as a new lesion or arising from nevi not monitored by dermatoscopy (40 % of melanomas detected in digital follow-up) [14]

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For example, thinner melanomas can often be treated with surgery alone

In addition, orlistat's potential to cause liver damage and its association with severe liver outcomes, such as gallstone formation, obstructive jaundice, and acute liver failure, have been documented [68, 70]