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Using human and mouse models, the researchers have verified that gut flora changes in pSS

Abstract Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4)

Strongly linked to obesity, type 2 diabetes, and metabolic syndrome, MASLD poses a growing health burden

In contrast to many other autoimmune diseases, plasma and saliva from female SS animal models collected after disease onset contain markedly elevated levels of several PRLMs, particularly RvD1 and RvD2, along with increased expression of their biosynthetic enzymes and corresponding receptors [287]