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10.1016/j.molcel.2018.10.040 Mol
Therefore, this evidence from various sources indicates that hypoxia increases the NADH pool leading to ROS generation and reductive stress
GSH depletion can trigger ferroptosis, which has been exploited in cancer treatments [17], and supplementation with GSH is utilized by glutathione peroxidase 4 (GPX4) to prevent lipid peroxidation, in turn inhibiting ferroptosis
