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Glutamine contributes to the synthesis of uridine diphosphate- N -acetylglucosamine (UDP-GlcNAc), which is part of the hexosamine biosynthesis pathway (HBP) and is required for protein glycosylation and endoplasmic reticulum stress response in tumor cells [6]

Furthermore, proteins can be monoubiquitinated, multiubiquitinated, and polyubiquitinated, which adds a certain depth to the pathway, as different types of linkages can activate different signaling pathways, through binding to specific ubiquitin binding domains (more than 20 have been discovered)

Heliyon 9 (7), e18321

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