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99 However, due to the wide absorption spectrum of melanin (250nm1200nm), laser energy intended for deeper targets can be absorbed within the pigmented epidermis, which can lead to complications such as dyschromias, blistering, and scars

The studies that produced the fat-loss results used injection, while the market sells oral capsules and credits the compound with "high oral bioavailability." The small size and membrane permeability that let it slip into cells make oral absorption plausible, and that is the rationale vendors lean on

10.1016/J.FERTNSTERT.2016.01.032 26 ClinicalTrials.gov

Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double- blind, placebo-controlled, phase 3 trial