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Supplementation can help

Evidence from clinical studies and systematic analyses indicates that long-term or moderately high doses of supplemental vitamin D can increase the risk of hypercalcemia in a small subset of individuals
Effects of supplemental vitamin D on bone health outcomes in women and men in the VITamin D and OmegA-3 TriaL (VITAL)

The presence of an active xanthine oxidase in mature RBCs was reported and challenged [95]
