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Is it true that this pathway is only active when the cell is under oxidative stress conditions

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Oestreich LK, Pasternak O, Shenton ME, Kubicki M, Gong X, Australian Schizophrenia Research B, et al

Curcumin is often described as a hormetic compound because it induces an adaptive stress response: it mildly stresses cells in ways that activate Nrf2 and other transcription factors, leading to increased production of antioxidant and cytoprotective proteins (e.g., heme oxygenase-1) that precondition cells against subsequent injuries (77, 78)