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SIRT1 activation by natural phytochemicals: an overview

Biochemically, due to intracellular GSH deprivation and GPX4 deactivation, lipid peroxides derived from Fe2+-catalyzed Fenton reaction fail to be eliminated through the GPX4-mediated reduction reaction, producing abundant reactive oxygen species (ROS), which facilitates ferroptosis (Stockwell et al., 2017

Disruption of its function has been identified in several neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and prion diseases, as well as in amyotrophic lateral sclerosis (ALS)

Together, they allow for broader experimental observation