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Under the stimulation of reactive oxygen species (ROS), it releases trans-differentiation inducers to induce the in situ trans-differentiation of Th17 cells into Treg cells for the treatment of MS (Shi et al., 2023)

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Yong, T

Itaconate is transported to the cytosol where several enzymes of glucose metabolism are inhibited including aldolase A (encoded by the ALDOA gene), glyceraldehyde-3-phosphate dehydrogenase (encoded by the GAPDH gene), lactate dehydrogenase (encoded by the LDHA gene), enolase (encoded by the ENO1 gene), and the PKM2 isoform of pyruvate kinase (encoded by the PKM gene)