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Breast cancer Initial studies of breast cancer risk associated with GPx-1 Pro198Leu polymorphisms reported a higher frequency of the Leu/Leu genotype in breast cancer tissues from African American women than the Pro/Pro genotype compared to the distribution of these genotypes in normal cancer free individuals (175)

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Revollo JR, Grimm AA, Imai SI (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells