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50 M Morin significantly upregulated the expression of MITF, as well as its downstream TRP-1 and Trp-2 to increase melanin production in B16F10 mouse melanoma cells, and the mechanisms include the activation of ERK and p38 signaling pathways via the phosphorylated MAPK pathway (Shin et al., 2021)

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246 In recent years, increasing evidence has shown that the PI3K/AKT signaling pathway is closely associated with the occurrence and development of UC and is also an important signaling pathway for targeted UC therapy

[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Nielsen T.K., Hojgaard M., Andersen J.T., Jorgensen N.R., Zerahn B., Kristensen B., Henriksen T., Lykkesfeldt J., Mikines K.J., Poulsen H.E