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Description
Intracellularly, CHAC1 enzymatically degrades GSH into 5-oxoproline and Cys-Gly, acting as a pro-ferroptotic execution signal by accelerating GSH exhaustion 151
pH jumping method This is another solvent-free method that was first reported by Hauser and colleagues where SUVs were formed because of pH jump to MLVs [40, 48]
Notably, these polyrotaxanes exhibited low cytotoxicity at therapeutically relevant doses, enhancing their potential for clinical applications
For longer use (3+ months), consider cycling
