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You should not take Accutane (isotretinoin) if you: Are under 12 years of age Are pregnant, trying to conceive, or breastfeeding (it causes severe birth defects)

Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target

The following is taken from the section, "How should treatment be given", from the peer-reviewed medical-journal article, "The Many Faces of Cobalamin (Vitamin B12) Deficiency": [Start quote] For parenteral therapy in cases of megaloblastic anemia, it has been advised to administer 1000 mg hydroxocobalamin IM twice weekly for a period of 5 weeks, and the dose is reduced to 1000 mg IM every 2 months thereafter