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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Paisan-Ruiz C., Jain S., Evans E.W., Gilks W.P., Simon J., van der Brug M., Lopez de Munain A., Aparicio S., Gil A.M., Khan N., et al
This oxidative stress damages mitochondrial components, including lipids, proteins, and mitochondrial DNA (mtDNA) [177]
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In recent years, IDH inhibitors targeting IDH mutants, including ivosidenib and enasidenib (Table 1), have been approved by the Food and Drug Administration to be used in patients with IDH1 or IDH2 mutant recurrent or refractory AML, respectively (Kim, 2017
