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Moreover, simultaneous administration of melatonin also decreased the IL-1 levels comparable to the S-methylisothiourea co-administration in mechlorethamine nephrotoxicity

The importance of these mechanisms in the development of AD, PD, ALS, and MS lies in the fact that neurons are especially vulnerable to ROS and RNS since they contain high levels of unsaturated lipids susceptible to oxidation and high levels of transition metals that catalyze the synthesis of free radicals [40]

Another meta-analysis of randomised trials suggested that supplementation with caffeine may reduce body weight in adults (Reference Tabrizi, Saneei and Lankarani10)
