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Cognitive Impairment Models: Dihexa has been tested in scopolamine-induced amnesia models and aged rat models, where it demonstrated restoration of cognitive performance on spatial memory tasks

(11) This has led to the hypothesis that exogenous FOXO protein, such as FOXO4-DRI peptide, may help regulate optimal levels of FOXO proteins, thereby preventing or alleviating the progression of any NDDs associated with this mechanism

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PLoS ONE 13(12):e0207534 Fedorov A, Suboch G, Bujakov M, Fedorova L (1992) Analysis of nonuniformity in intron phase distribution