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Disruption of circadian rhythms by constant light also deteriorates heart function, further confirming clocks role in maintaining heart homeostasis (Melkani et al., 2017)

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This provides the heart with the amount of ATP necessary for a cardiac muscle demand of 100,000 beats daily [24]

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1 Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the loss of upper and lower motor neurons, ALS patients mainly are with muscle weakness, stiffness and atrophy

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