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Berberine (alkaloid) in a 2023 rat study prevented rotenoneinduced motor impairment: berberinetreated PD rats performed better on locomotor and coordination tasks (open field, rotarod, etc.) compared to untreated PD rats [44]

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This contrasted with the spared gross liver presentation, counteracted hepatomegaly and splenomegaly, reduced gross lesions in the stomach, duodenum and intestine, lower serum enzyme values, and no congestion of the central vein or branches of the terminal portal venules in BPC 157-treated rats