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The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)

Ziegler AN, Feng Q, Chidambaram S, Testai JM, Kumari E, Rothbard DE, Constancia M, Sandovici I, Cominski T, Pang K, et al

doi: 10.1007/s00299-023-02989-9 14 GuoJ.SunB.HeH.ZhangY.TianH.WangB

While extrapolated data from UK/US, CF clinics suggest a prevalence of 1:12,0001:40,000 among Indian children (95), a 2020 North Indian study revealed a high CFTR mutation carrier rate of 1:22, signaling a potentially higher prevalence (96)