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155,156 While corticosteroids have shown limited efficacy and potential adverse effects in clinical trials, NSAIDs, particularly those with selective cyclooxygenase-2 inhibition, have demonstrated some protective effects in experimental models

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However, the study noted that there was significant variation in the quality of the methodology used, indicating that more well-designed clinical trials are needed to further investigate the potential benefits of saffron

The WHO global report 2023 on hypertension warning the emerging hypertension burden in Globe and its treatment strategy