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That is the honest research framing

The clinical pharmacologists/scientists should be aware of the literature, as well as in vitro and preclinical pharmacology models to determine if a suitable candidate biomarker should be included in an FIH study

10.1016/j.bbr.2013.08.005 151 LammelS.HetzelA.HckelO.JonesI.LissB.RoeperJ

The characteristics of subjects were similar across the treatment sequences: the mean age range was 24.2-38.0 years, mean weight 65.0-76.5 kg and mean BMI 23.0-24.8 kg/m 2 , and the number of subjects per sequence ranged between 1 and 4
