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Description
The R248W and R273H mutations attribute Mre11 nuclease-binding capacity to the p53 protein to prevent association of the Mre11-Rad50-NBS1 (MRN) complex with DNA double-strand breaks, thereby impairing ataxia-telangiectasia mutated (ATM) activation and the DNA damage response (Calheiros et al
Palmieri L, Malvezzi H, Cestari B, Podgaec S
P., & Sahebkar, A
doi: 10.1089/ars.2012.5149 143 MiyakeM.OdaY.OwariT.IidaK.OhnishiS.FujiiT.et al
